CGA-IGC TOOLKITS
Our toolkits aggregate various CGA-IGC resources and those from other stakeholders with the aim to support the needs and interests of the multidisciplinary hereditary GI cancer community
Early Onset Colorectal Cancer (eoCRC) Toolkit
If you know of a resource that CGA-IGC should include in our toolkits, contact us at info@cgaigc.com
Early Onset Colorectal Cancer (eoCRC) Toolkit
Key
Podcasts
Webinars
Web resources
RISING RATES OF EARLY ONSET COLORECTAL CANCER
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Why Are Colorectal Cancer Patients Getting Younger?
Released March 2025
Swati G. Patel from the Anschutz Medical Centre, UoC, talks with the Health Science Radio at the University of Colorado Anschutz Medical Campus. They discuss the epidemiological factors behind early-onset colorectal cancer, the age groups being affected, symptoms people should be paying attention to, preventative screening options, and where the research is going to try to reverse this alarming trend.
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​Colorectal Cancer Incidence Is Rising in Young Adults
ACS Podcast
Released August 2024
Steven D. Wexner, a colorectal surgeon from the Cleveland Clinic in Florida, talks with Matthew F. Kalady, a widely recognized expert in colorectal cancer and its hereditary syndromes. They discuss incidence, treatment options, and the importance of awareness and outreach.
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From the Archive: Insights on Young-Onset Colorectal Cancer
ASCO Post Podcast
Released July 2023
Kimmie Ng from Dana Farber shares her insights on the rising rates of colorectal cancer among young adults.
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In conversation with Swati G. Patel
The Lancet Gastroenterology and Hepatology
Swati G. Patel from Anschutz Medical Centre, UoC, the rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection
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Colorectal cancer on the rise in younger adults
Mayo Clinic Q & A Podcast
Released March 2022
Halena Gazelka interviews Jeremy Jones about the rise of colorectal cancer among younger adults.
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Colon Cancer, Nuts, and Early Onset
UCONN Health Pulse
Released March 2022
Daniel Rosenburg discusses the connection between our gut microbiome, inflammation, and early onset colon cancer.
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Investigating the rise of early-onset colorectal cancer
American Cancer Society Theory Lab
Released February 2021
Peter Campbell shares data and hypotheses to explain the rise of colorectal cancer in young individuals, also addressing racial and ethnic colorectal cancer disparities.
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Cancer Topics- Young Onset Colorectal Cancer
ASCO Education Podcast
Released July 2021
Nilofer Azad and epidemiologist Caitlin Murphy discuss risk factors, screening and treatment for people diagnosed with colorectal cancer under the age of 50.
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Speaking out on early-age onset colorectal cancer
Cure Today - Cancer Horizons
Released January 2020
Zsofia Stadler reviews sign and symptoms of early onset colorectal cancer and shares updates on colorectal screening guidelines.
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DISPARITIES IN EARLY ONSET COLORECTAL CANCER
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Homelessness and CRC Screening
Tabooty- Fight CRC Podcast
Released May 2019
Liz Brockland discusses her work in Chicago with North Side Housing and Supportive Services. Among other things, Liz, a community health nurse, helps previously homeless individuals access colorectal cancer screening.
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Racial/Ethnic Differences Discovered in Multigene Germline Testing of Early-Onset Colorectal Cancer
JCO After Hours Podcast
Released July 2023
Shannon West interviews Andreana N. Holowatyj about her paper: “Clinical Multigene Panel Testing Identifies Racial and Ethnic Differences in Germline Pathogenic Variants Among Patients With Early-Onset Colorectal Cancer.”
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Tackling the Increasing Incident of Early-Onset Colorectal Cancer
ASCO Daily News
Released November 2021
Mohamed Salem discusses rise of early onset colorectal cancer and the impact of socioeconomic disparities on patient outcomes and potential interventions to improve detection.
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Baptist Health Podcast
Released March 2021
Ron Landmann discusses MD Anderson Cancer Center and Borland Groover’s joint campaign to complete colon cancer screenings for Baptist Health employees and improve the screening rates for African-Americans in their community.
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PATIENT CARE IN EARLY ONSET COLORECTAL CANCER
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In conversation with Danielle Ripley Burgess – Life After Total Proctocolectomy in Lynch Syndrome
CGA-IGC Podcast 2023
Released November 2023
Danielle Ripley-Burgess shares her story and experience on "Life After Total Proctocolectomy in Lynch Syndrome.”
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​Patient Perspectives- Young Onset Colorectal Cancer
Butts & Guts, a Cleveland Clinic Podcast
Released November 2021
Scott Steele, chair of colorectal surgery at Cleveland Clinic interviews patient Brittney Ferguson, his patient who was diagnosed with early onset rectal cancer at 37.
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Cleveland Clinic’s Center for young-Onset Colorectal Cancer
Cleveland Clinic Cancer Advances
Released December 2021
Suneel Kamath, a hematologist and medical oncologist at Cleveland Clinic discusses how the Center for Young-Onset Colorectal Cancer was established, and how it allows comprehensive and multidisciplinary approach to research, diagnosis and treatment of young onset colorectal cancer.
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Colorectal Cancer in Young Adults
UFHealth MedEd Cast
Released March 2021
Brian Ramnaraign discusses the clinical indications for screening colonoscopy in young adults.
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Colorectal Cancer Under 50
Tabooty- Fight CRC Podcast
Released May 2020
Michael, a colorectal cancer survivor, speaks about his experience, symptoms, emotions around diagnosis treatment, and in particular around ostomy, reversal and LARS.
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Transitioning from Pediatric to Adult Care for Patients with FAP
CGA-IGC Podcast 2019
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PATIENT RESOURCES
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Millennial? Gen Z? It might be time for colorectal cancer screening
NPR Life Kit
Released August 2023
Marielle Segarra discusses rise of colorectal cancer among young people.
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Preimplantation Genetic Testing
Tabooty- Fight CRC Podcast
Released October 2018
Interview with Serena Talcott Baughman about preimplantation genetic testing.
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Ostomy Care with Joanna Burgess
Tabooty- Fight CRC Podcast
Released March 2018
Joanna Burgess, wound, ostomy and continence nurse, answers common questions people about ostomy.
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In conversation with Molly McMaster Morgoslepov,
AliveAndKickn podcast
Released June 2021
Molly McMaster Morgoslepov survived colon cancer in her 20s and went on to become a patient advocate for others who face the same diagnosis.
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Fight CRC Tabooty Podcast
Released July 2021
Apple Podcasts
Jaime Bruce shares tips and suggestions on how to talk with kids about cancer.
Save the Booties: Early Onset Colorectal Cancer
Fight CRC Webinar
Released September 2024
Fight CRC dives into the research around early onset cancer, what we are doing to address this problem, and a discussion around the unique challenges that young adults experience when faced with a CRC diagnosis.
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​Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt), an interview with Swati G. Patel, Giulia Cavestro, Alessandro Mannucci, & Marta Puzzono taking a closer look at the #eoCRC initiative and the work of the DIRECt group. Released March 2023.
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CGA-IGC 2022 Annual Meeting:
Released November 2022.
Preimplantation Genetic Diagnosis, Andria Besser explains the current landscape of preimplantation genetic testing for hereditary cancer syndromes.
Oncofertility, Sukhkamal Campbell provides education about fertility preservation prior to therapy initiation for females with early-onset cancer diagnoses.
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Delphi Initiative Recommendations on Early Onset Colorectal Cancer (DIRECt), Giulia Martina Cavestro presents the work done by DIRECt.
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CGA-IGC 2021 Annual Meeting:
The 2021 CGA-IGC virtual meeting featured a session on early-onset colorectal cancer.
Released November 2021.
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Epidemiology of eoCRC Caitlin Murphy
Genetics & Epigenetic Landscape of eoCRC, Andreana N. Holowatyj
Gut Microbiome in eoCRC, Phil Quirke
eoCRC in Pediatric Population, Surgical Perspective, Andrea Hayes-Jordan
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CGA-IGC 2018-19 Webinar Series 1:
Elena Stoffel addresses the increasing incidence of early-onset colorectal cancer and reviews data regarding the genetic, lifestyle, and environmental causes and tumor biology of eoCRC
Released December 2019.
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Colon Cancer Alliance is a non-profit dedicated to colorectal cancer, as they advocate for prevention, support, and research. They provide many resources, including young-onset colorectal cancer support.
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The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection of early onset colorectal cancer.
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The histological and molecular characteristics of early-onset colorectal cancer: a systematic review and meta-analysis concerning the prevalence of prognostic and predictive tumor markers for early- vs. late-onset colorectal cancer.
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Temporal Trends in Racial and Gender Disparities of Early Onset Colorectal Cancer in the United States: An Analysis of the CDC WONDER Database to identify disparities potentially influencing these rates, enhancing risk assessment tools, and highlighting areas necessitating further research.
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Unraveling the complexities of early-onset colorectal cancer: a perspective on dietary and microbial influences. Retrospective study evaluating the influence of metabolic factors on EOCRC with an overall review of dietary trends.
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Early onset colorectal cancer: Challenges across the cancer care continuum.
​​​Series| Early-Onset Colorectal Cancer
The Lancet Gastroenterology & Hepatology
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Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines, covering the full spectrum of care.
*Clinical Gastroenterology and Hepatology.
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Fight CRC eoCRC Workgroup, a global, multidisciplinary working group to explore sporadic early-onset colorectal cancer, or cancer in young adults that is not linked to an inherited or genetic predisposition.
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Fight CRC Rally on eoCRC Research co-hosted by Jose Perea Garcia, CGA-IGC Meeting Planning Member, and Fight CRC.
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Patient resources by Colon Club, patient advocacy group for eoCRC.
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​Early-onset colorectal cancer risk extends to second- and third-degree relatives, an article estimated the risk to first-, second-, and third-degree relatives of EO-CRC cases in the Utah Pedigree Database.
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Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults This review provides an overview on epidemiologic trends in CRC, data on genetic and non-genetic risk factors, and new approaches for determining CRC risk.
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Calculating the Starting Age for Screening in Relatives of Patients With Colorectal Cancer Based on Data From Large Nationwide Data Sets This articles provides risk-adapted recommendations on the starting age of CRC screening for individuals with different family histories.
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A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers
This article sought to determine if early-onset colorectal cancer is clinically or genomically distinct from average-onset colorectal cancer.
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A Coordinated Clinical Center for Young Onset Colorectal Cancer
This article describes the lessons learned of the first 2 years at the Center for Young Onset Colorectal Cancer at the Memorial Sloan Kettering Cancer Center, including development of the program and specific services provided.
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Abbreviated bibliography on key eoCRC resources.
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Content reflects expert opinion at time of publication
*Journal credit: Clinical Gastroenterology and Hepatology 2023;21:581–603
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Last reviewed: March 2025
LGBTQI+ Toolkit
Key
Podcasts
Webinars
Web resources
Online learning
Creating Breast and Gynecologic Cancer Guidelines for Transgender Patients With BRCA Mutations, Bronwyn Bedrick, discusses this guidance statement, published in Obstretics & Gynecology.
Released March 2022
CGA-IGC Podcast S5EP1
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5 Pearls on Transgender Health - Episode 1 & Episode 2, the physician hosts of the CoreIM podcast provide a 2-part series on transgender healthcare services. Released March & April 2020.
CoreIM podcasts
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CGA-IGC 2022 Annual Meeting
Released November 2022.
Case Report: Non-Binary Patient with a Germline {CDH1} Pathogenic Variant: Counseling and Clinical Considerations, Megha Ranganathan highlights several themes, including the importance of confirming gender identity and pronouns, challenges associated
with coordination of care, and lack of non-binary specific medical training.
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CGA-IGC 2022 Webinar Series 4 Caring for our LGBTQI+ Patients
Sonali Paul, reviews the LGBTQI+ narrative illustrates that there are many social determinants of health based on discrimination that affect LGBTQI+ individuals and their health outcomes; routinely capturing sexual orientation and gender identity data can help improve the doctor-patient relationship and decrease health disparities. Released February 2022.
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CGA-IGC 2021 Annual Meeting
The 2021 CGA-IGC virtual meeting featured sessions on topics around treatment & care for LGBTQI+ patients. Released November 2021.
Gynecologic Cancer Risk-Reduction Considerations in Trans/Non-Binary Lynch Syndrome Patients, Iris Romero.
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Advancing Health Equity Abstract Presentation I Management of a transgender male with Lynch syndrome, Lauren Gima.
NEW: Cancer surveillance for transgender and gender diverse patients with Lynch syndrome - a practice resource of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer.
NEW: Variations of Sex Characteristics (VSC) - A Guide for Cancer Genetics Providers - the CGA-IGC JEDI Committee provides a framework for how to approach care for an individual with both a Variation of Sex Characteristics (VSC) and a hereditary cancer syndrome.
The HRC Foundation - works with health care facilities that are committed to providing inclusive care to their LGBTQ+ patients. Going beyond inclusive non-discrimination policies, these facilities are adopting best practices in the areas of LGBTQ+ patient care and support, employee policies and benefits, and LGBTQ+ patient and community engagement.
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Fenway Health - links to Education & Training. Fenway Health exists to make life healthier for the people in our neighborhood, the LGBTQIA+ community, people living with HIV/AIDS and the broader population.
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National LGBTQIA+ Health Education Center - features publications, archived webinars, demonstration videos, learning modules and more all available at no cost. CMEs are also available.
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Clinical Care Options (CCO) - links to HCP-patient interaction video capturing best practices for the use of gender-neutral language for anatomy during cancer screenings for transgender patients.
Members only - Join or Login
Last reviewed: May 2024
Research Toolkit
Key
Podcasts
Webinars
Research Collaborations Series
Podcast 1: LINEAGE Consortium Joshua Melson, from the University of Arizona Cancer Center, sits down with leading experts from the LINEAGE Consortium, Swati G. Patel from the Anschutz Medical Centre, UoC, Zachariah H. Foda from Johns Hopkins and Holli Loomans-Kropp from Ohio State University. LINEAGE —a cutting-edge research collaboration tackling the complexities of Lynch Syndrome. This hereditary GI cancer syndrome affects 1 in 279 individuals yet remains vastly underdiagnosed due to its diverse presentation and variable penetrance. The LINEAGE Consortium is on a mission to change that. Read our communication committee member Alessandro Mannucci's podcast summary.
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Podcast 2: Gastric CDH1 Multicenter Consortium.
Emma Keel, MS, CCG, from the University of Chicago, interviews Ophir Gilad, MD, also from the University of Chicago and the lead of the Gastric CDH1 Multicenter Consortium.
This episode is a must-listen for clinicians, researchers, and anyone interested in hereditary gastrointestinal cancer syndromes. It showcases the power of collaboration and the potential for building successful research consortiums to advance our understanding of complex genetic conditions like CDH1-related gastric cancer.
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Podcast 3: International Replication Repair Deficiency Consortium (IRRDC)
Emma Keel, MS, CCG spoke with Melyssa Aronson, MSc, CGC and Lucie Stengs, BSc, from the International Replication Repair Deficiency Consortium (IRRDC).
This episode is essential listening for clinicians, researchers, and anyone interested in hereditary GI cancer syndromes research. Learn about this consortium's evolution from a local registry to an international collaboration studying rare genetic disorders, particularly CMMRD. It provides insights about the progress in developing diagnostic tools, establishing a biobank, and conducting research on potential treatments, including immunotherapy and vaccines. Also the challenges of managing the growing consortium, emphasized the importance of patient advocacy and international collaboration.
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2025 CGA-IGC Research Committee Webinar
"Transforming Cancer Prevention for Lynch Syndrome: Insights and Innovations,"
Ajay Bansal, MD from the Prevention Clinic, University of Kansas Health System and Holli Loomans-Kropp, PhD, MPH, from the Division of Cancer Prevention and Control, Ohio State University, share the current state of cancer prevention modalities for individuals with Lynch Syndrome, and discuss ongoing trials in this space. Released June 2025.
2024 CGA-IGC Research Committee Webinar
Mariana C. Stern, PhD from the Keck School of Medicine of USC, and Peter Lance, MD from the University of Arizona share their real-world experience in reducing barriers to participation in CRC research in underserved groups. Read our communication committee member Ophir Gilad's webinar summary. Released March 2024.
“How We Do It”: Programs Implemented to Maximize Workflows and Improve Patient Care."
The webinar featured two segments: the first discusses the use of Epic EMR in precision oncology at TriHealth Community Cancer Center, highlighting the need for an integrated genomics platform and strategies for optimizing EMR implementation. The second segment focuses on Memorial Sloan Kettering's inclusive genetic testing models, such as the MSK-IMPACT platform, to assess somatic mosaicism and explore additional testing strategies that could better inform patient management. Read our communication committee member Rita Matos' webinar summary. Released November 2023.
2023 CGA-IGC Research Committee Webinar
Have you ever been frustrated or confused about extracting data from the electronic health record or managing data for research studies? Learn more from our three speakers about the essentials of data management in this webinar!
Released July 2023.
2022 CGA-IGC Research Committee Webinar
"Tips and Tricks for the development of a Clinical Registry"
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Last reviewed: March 2025