CGA-IGC TOOLKITS
Our toolkits aggregate various CGA-IGC resources and those from other stakeholders with the aim to support the needs and interests of the multidisciplinary hereditary GI cancer community
Early Onset Colorectal Cancer (eoCRC) Toolkit
If you know of a resource that CGA-IGC should include in our toolkits, contact us at info@cgaigc.com
Early Onset Colorectal Cancer (eoCRC) Toolkit
Key
Podcasts
Webinars
Web resources
RISING RATES OF EARLY ONSET COLORECTAL CANCER
The Rise of Early -Onset and Rare GI Cancers
Released December 2025
Cathy Eng, Vanderbilt-Ingram Cancer Center, discusses the biological drivers behind EOCRC, the critical role of molecular profiling at the time of diagnosis, and how to structure a multidisciplinary young-adult cancer program.
Global Perspectives on Early Onset Colorectal Cancer
Fight CRC's lead research advisor and leader of the Global Think Tank for Early-Onset Colorectal Cancer, Andrea "Andi" Dwyer, MPH, and Fight CRC's Director of Research Advocacy the initiative's co-leader, Kiran Ilagan, DrPH, CHES provide a summary of the 2025 Global Think Tank findings. This episode explains the "birth cohort effect" (why those born in 1990 have 4x the risk of rectal cancer) and identifies international differences in how EOCRC is presenting across different continents.
Why Are Early-Onset GI Cancers on the Rise?
Released August 2025
Monty Pal, medical oncologist, professor and vice chair of medical oncology at the City of Hope Comprehensive Cancer Center in Los Angeles. speaks with Dr. Kimmie Ng, to discuss the rise of early-onset GI cancers.
Rise in Early-Onset Colon Cancer Being Studied Through Single-Cell Sequencing
Released June 2025
Joel Gabre, a gastroenterologist at New York-Presbyterian and Columbia who specializes in cancer care, discusses the ongoing rise in colorectal cancer rates among younger individuals.
Why Are Colorectal Cancer Patients Getting Younger?
Released March 2025
Swati G. Patel from the Anschutz Medical Centre, UoC, talks with the Health Science Radio at the University of Colorado Anschutz Medical Campus. They discuss the epidemiological factors behind early-onset colorectal cancer, the age groups being affected, symptoms people should be paying attention to, preventative screening options, and where the research is going to try to reverse this alarming trend.
Colorectal Cancer Incidence Is Rising in Young Adults
ACS Podcast
Released August 2024
Steven D. Wexner, a colorectal surgeon from the Cleveland Clinic in Florida, talks with Matthew F. Kalady, a widely recognized expert in colorectal cancer and its hereditary syndromes. They discuss incidence, treatment options, and the importance of awareness and outreach.
The Rise of Colorectal Cancers Among Younger People
Released June 2024
Otis Brawley, MD, a globally recognized expert in cancer prevention and control whose work focuses on developing cancer screening strategies and ensuring their effectiveness.
From the Archive: Insights on Young-Onset Colorectal Cancer
ASCO Post Podcast
Released July 2023
Kimmie Ng from Dana Farber shares her insights on the rising rates of colorectal cancer among young adults.
In conversation with Swati G. Patel
The Lancet Gastroenterology and Hepatology
Swati G. Patel from Anschutz Medical Centre, UoC, the rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection
DISPARITIES IN EARLY ONSET COLORECTAL CANCER
Racial/Ethnic Differences Discovered in Multigene Germline Testing of Early-Onset Colorectal Cancer
JCO After Hours Podcast
Released July 2023
Shannon West interviews Andreana N. Holowatyj about her paper: “Clinical Multigene Panel Testing Identifies Racial and Ethnic Differences in Germline Pathogenic Variants Among Patients With Early-Onset Colorectal Cancer.”
Tackling the Increasing Incident of Early-Onset Colorectal Cancer
ASCO Daily News
Released November 2021
Mohamed Salem discusses rise of early onset colorectal cancer and the impact of socioeconomic disparities on patient outcomes and potential interventions to improve detection.
PATIENT CARE IN EARLY ONSET COLORECTAL CANCER
In conversation with Danielle Ripley Burgess – Life After Total Proctocolectomy in Lynch Syndrome
CGA-IGC Podcast 2023
Released November 2023
Danielle Ripley-Burgess shares her story and experience on "Life After Total Proctocolectomy in Lynch Syndrome.”
Patient Perspectives- Young Onset Colorectal Cancer
Butts & Guts, a Cleveland Clinic Podcast
Released November 2021
Scott Steele, chair of colorectal surgery at Cleveland Clinic interviews patient Brittney Ferguson, his patient who was diagnosed with early onset rectal cancer at 37.
Cleveland Clinic’s Center for young-Onset Colorectal Cancer
Cleveland Clinic Cancer Advances
Released December 2021
Suneel Kamath, a hematologist and medical oncologist at Cleveland Clinic discusses how the Center for Young-Onset Colorectal Cancer was established, and how it allows comprehensive and multidisciplinary approach to research, diagnosis and treatment of young onset colorectal cancer.
Colorectal Cancer in Young Adults
UFHealth MedEd Cast
Released March 2021
Brian Ramnaraign discusses the clinical indications for screening colonoscopy in young adults.
Transitioning from Pediatric to Adult Care for Patients with FAP
CGA-IGC Podcast 2019
PATIENT RESOURCES
Millennial? Gen Z? It might be time for colorectal cancer screening
NPR Life Kit
Released August 2023
Marielle Segarra discusses rise of colorectal cancer among young people.
Preimplantation Genetic Testing
Tabooty- Fight CRC Podcast
Released October 2018
Interview with Serena Talcott Baughman about preimplantation genetic testing.
Ostomy Care with Joanna Burgess
Tabooty- Fight CRC Podcast
Released March 2018
Joanna Burgess, wound, ostomy and continence nurse, answers common questions people about ostomy.
Fight CRC Tabooty Podcast (bottom)
Released July 2021
Jaime Bruce shares tips and suggestions on how to talk with kids about cancer.
February 2026
A panel featuring Cathy Eng, Y. Nancy You, David Liska discussing how to build a dedicated young-onset clinic, with key topics including multidisciplinary care models, unique psychosocial needs of young adults, and integrating fertility preservation into the surgical plan.
Released February 2026
WashU in St. Louis Medicine Grand Rounds talk by Cassandra Fritz focused on understanding the etiology of the rise in EoCRC cases and paths forward for earlier detection in primary care and GI settings
Rising Rate, Early Detection: Understanding Early-Onset Colorectal Cancer
Released July 2025
Nilo Azad and John Migaly discuss the growing incidence of early-onset colorectal cancer (EOCRC) and the latest strategies for detection, treatment, and prevention.
CGA-IGC Webinar 3: How We Do It: Care of AYAs
Released May 2025
Stacy Hines-Dowell, DNP, FNP-BC, AGN-BC, ACGN; Melissa Perrino, MD; and Rose McGee, MS, CGC.
provide valuable guidance and shared real-world examples to support a smooth, patient-centered transition from pediatric to adult healthcare systems for individuals at risk.
Save the Booties: Early Onset Colorectal Cancer
Fight CRC Webinar
Released September 2024
Fight CRC dives into the research around early onset cancer, what we are doing to address this problem, and a discussion around the unique challenges that young adults experience when faced with a CRC diagnosis.
Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt), an interview with Swati G. Patel, Giulia Cavestro, Alessandro Mannucci, & Marta Puzzono taking a closer look at the #eoCRC initiative and the work of the DIRECt group. Released March 2023.
CGA-IGC 2022 Annual Meeting:
Released November 2022.
Preimplantation Genetic Diagnosis, Andria Besser explains the current landscape of preimplantation genetic testing for hereditary cancer syndromes.
Sukhkamal Campbell provides education about fertility preservation prior to therapy initiation for females with early-onset cancer diagnoses.
Colon Cancer Alliance is a non-profit dedicated to colorectal cancer, as they advocate for prevention, support, and research. They provide many resources, including young-onset colorectal cancer support.
Early-onset colorectal cancer is associated with metabolic disorders: a systematic review and meta-analysis - One of the strongest meta-analyses linking metabolic syndrome, obesity, diabetes, and insulin resistance with EO-CRC risk, supports metabolic health as a major modifiable driver.
Clinicopathological characteristics and biomarker alterations in early-onset vs. late-onset colorectal cancer: a systematic review and meta-analysis Int J Surg. 2026
Approach Toward Early Detection and Prevention of Early-Onset Colorectal Cancer Annu Rev Med. 2026
2025 Global Early-Onset Colorectal Cancer Think Tank (GEOCRCTT) Summary Report summarizes a landmark gathering of 71 experts and advocates from 18 countries held in Barcelona, Spain, in June 2025. It outlines a global strategic roadmap to combat the rising incidence of early-onset colorectal cancer by synchronizing international research on biological and environmental risk factors, standardizing global data collection, and developing unified clinical protocols for earlier risk stratification and diagnosis.
Early onset colorectal cancer - an authoritative state-of-the-art clinical review summarizing epidemiology, diagnostic delays, risk factors, screening implications, and clinical red flags, providing primary-care and gastroenterology practice guidance on symptom recognition and referral.
Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry dat Lancet Oncology 2025
Prognosis of early-onset versus late-onset sporadic colorectal cancer: Systematic review and meta-analysis. Eur J Cancer 2025
Patterns in genomic mutations among patients with early-onset colorectal cancer: an international, multicohort, observational study. Lancet Oncology 2025
Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry dat Lancet Oncology 2025
The histological and molecular characteristics of early-onset colorectal cancer: a systematic review and meta-analysis concerning the prevalence of prognostic and predictive tumor markers for early- vs. late-onset colorectal cancer.
Differences in characteristics and outcomes between early-onset colorectal cancer and late-onset colorectal cancers Eur J Surg Onc 2024
Temporal Trends in Racial and Gender Disparities of Early Onset Colorectal Cancer in the United States: An Analysis of the CDC WONDER Database to identify disparities potentially influencing these rates, enhancing risk assessment tools, and highlighting areas necessitating further research.
Unraveling the complexities of early-onset colorectal cancer: a perspective on dietary and microbial influences. Retrospective study evaluating the influence of metabolic factors on EOCRC with an overall review of dietary trends.
Early onset colorectal cancer: Challenges across the cancer care continuum.
Increasing Incidence of Early-Onset Colorectal Cancer. NEJM 2022
Series| Early-Onset Colorectal Cancer
The Lancet Gastroenterology & Hepatology. This series includes, 2 papers:
The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection of early onset colorectal cancer.
A comprehensive framework for early-onset colorectal cancer research Lancet Oncology. 2022
Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines, covering the full spectrum of care.
*Clinical Gastroenterology and Hepatology.
Fight CRC eoCRC Workgroup, a global, multidisciplinary working group to explore sporadic early-onset colorectal cancer, or cancer in young adults that is not linked to an inherited or genetic predisposition.
Early-onset colorectal cancer risk extends to second- and third-degree relatives, an article estimated the risk to first-, second-, and third-degree relatives of EO-CRC cases in the Utah Pedigree Database.
Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults This review provides an overview on epidemiologic trends in CRC, data on genetic and non-genetic risk factors, and new approaches for determining CRC risk.
Calculating the Starting Age for Screening in Relatives of Patients With Colorectal Cancer Based on Data From Large Nationwide Data Sets This articles provides risk-adapted recommendations on the starting age of CRC screening for individuals with different family histories.
A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers
This article sought to determine if early-onset colorectal cancer is clinically or genomically distinct from average-onset colorectal cancer.
A Coordinated Clinical Center for Young Onset Colorectal Cancer
This article describes the lessons learned of the first 2 years at the Center for Young Onset Colorectal Cancer at the Memorial Sloan Kettering Cancer Center, including development of the program and specific services provided.
Abbreviated bibliography on key eoCRC resources.
Content reflects expert opinion at time of publication
*Journal credit: Clinical Gastroenterology and Hepatology 2023;21:581–603
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Last reviewed: March 2026
LGBTQI+ Toolkit
Key
Podcasts
Webinars
Web resources
Online learning
Creating Breast and Gynecologic Cancer Guidelines for Transgender Patients With BRCA Mutations, Bronwyn Bedrick, discusses this guidance statement, published in Obstretics & Gynecology.
Released March 2022
CGA-IGC Podcast S5EP1
5 Pearls on Transgender Health - Episode 1 & Episode 2, the physician hosts of the CoreIM podcast provide a 2-part series on transgender healthcare services. Released March & April 2020.
CoreIM podcasts
CGA-IGC 2022 Annual Meeting
Released November 2022.
Case Report: Non-Binary Patient with a Germline {CDH1} Pathogenic Variant: Counseling and Clinical Considerations, Megha Ranganathan highlights several themes, including the importance of confirming gender identity and pronouns, challenges associated
with coordination of care, and lack of non-binary specific medical training.
CGA-IGC 2022 Webinar Series 4 Caring for our LGBTQI+ Patients
Sonali Paul, reviews the LGBTQI+ narrative illustrates that there are many social determinants of health based on discrimination that affect LGBTQI+ individuals and their health outcomes; routinely capturing sexual orientation and gender identity data can help improve the doctor-patient relationship and decrease health disparities. Released February 2022.
CGA-IGC 2021 Annual Meeting
The 2021 CGA-IGC virtual meeting featured sessions on topics around treatment & care for LGBTQI+ patients. Released November 2021.
Gynecologic Cancer Risk-Reduction Considerations in Trans/Non-Binary Lynch Syndrome Patients, Iris Romero.
Advancing Health Equity Abstract Presentation I Management of a transgender male with Lynch syndrome, Lauren Gima.
NEW: Cancer surveillance for transgender and gender diverse patients with Lynch syndrome - a practice resource of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer.
NEW: Variations of Sex Characteristics (VSC) - A Guide for Cancer Genetics Providers - the CGA-IGC JEDI Committee provides a framework for how to approach care for an individual with both a Variation of Sex Characteristics (VSC) and a hereditary cancer syndrome.
The HRC Foundation - works with health care facilities that are committed to providing inclusive care to their LGBTQ+ patients. Going beyond inclusive non-discrimination policies, these facilities are adopting best practices in the areas of LGBTQ+ patient care and support, employee policies and benefits, and LGBTQ+ patient and community engagement.
Fenway Health - links to Education & Training. Fenway Health exists to make life healthier for the people in our neighborhood, the LGBTQIA+ community, people living with HIV/AIDS and the broader population.
National LGBTQIA+ Health Education Center - features publications, archived webinars, demonstration videos, learning modules and more all available at no cost. CMEs are also available.
Clinical Care Options (CCO) - links to HCP-patient interaction video capturing best practices for the use of gender-neutral language for anatomy during cancer screenings for transgender patients.
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Last reviewed: May 2024
Research Toolkit
Key
Podcasts
Webinars
Research Collaborations Series
Podcast 1: LINEAGE Consortium Joshua Melson, from the University of Arizona Cancer Center, sits down with leading experts from the LINEAGE Consortium, Swati G. Patel from the Anschutz Medical Centre, UoC, Zachariah H. Foda from Johns Hopkins and Holli Loomans-Kropp from Ohio State University. LINEAGE —a cutting-edge research collaboration tackling the complexities of Lynch Syndrome. This hereditary GI cancer syndrome affects 1 in 279 individuals yet remains vastly underdiagnosed due to its diverse presentation and variable penetrance. The LINEAGE Consortium is on a mission to change that. Read our communication committee member Alessandro Mannucci's podcast summary.
Podcast 2: Gastric CDH1 Multicenter Consortium.
Emma Keel, MS, CCG, from the University of Chicago, interviews Ophir Gilad, MD, also from the University of Chicago and the lead of the Gastric CDH1 Multicenter Consortium.
This episode is a must-listen for clinicians, researchers, and anyone interested in hereditary gastrointestinal cancer syndromes. It showcases the power of collaboration and the potential for building successful research consortiums to advance our understanding of complex genetic conditions like CDH1-related gastric cancer.
Podcast 3: International Replication Repair Deficiency Consortium (IRRDC)
Emma Keel, MS, CCG spoke with Melyssa Aronson, MSc, CGC and Lucie Stengs, BSc, from the International Replication Repair Deficiency Consortium (IRRDC).
This episode is essential listening for clinicians, researchers, and anyone interested in hereditary GI cancer syndromes research. Learn about this consortium's evolution from a local registry to an international collaboration studying rare genetic disorders, particularly CMMRD. It provides insights about the progress in developing diagnostic tools, establishing a biobank, and conducting research on potential treatments, including immunotherapy and vaccines. Also the challenges of managing the growing consortium, emphasized the importance of patient advocacy and international collaboration.
2025 CGA-IGC Research Committee Webinar
"Transforming Cancer Prevention for Lynch Syndrome: Insights and Innovations,"
Ajay Bansal, MD from the Prevention Clinic, University of Kansas Health System and Holli Loomans-Kropp, PhD, MPH, from the Division of Cancer Prevention and Control, Ohio State University, share the current state of cancer prevention modalities for individuals with Lynch Syndrome, and discuss ongoing trials in this space. Released June 2025.
2024 CGA-IGC Research Committee Webinar
Mariana C. Stern, PhD from the Keck School of Medicine of USC, and Peter Lance, MD from the University of Arizona share their real-world experience in reducing barriers to participation in CRC research in underserved groups. Read our communication committee member Ophir Gilad's webinar summary. Released March 2024.
“How We Do It”: Programs Implemented to Maximize Workflows and Improve Patient Care."
The webinar featured two segments: the first discusses the use of Epic EMR in precision oncology at TriHealth Community Cancer Center, highlighting the need for an integrated genomics platform and strategies for optimizing EMR implementation. The second segment focuses on Memorial Sloan Kettering's inclusive genetic testing models, such as the MSK-IMPACT platform, to assess somatic mosaicism and explore additional testing strategies that could better inform patient management. Read our communication committee member Rita Matos' webinar summary. Released November 2023.
2023 CGA-IGC Research Committee Webinar
Have you ever been frustrated or confused about extracting data from the electronic health record or managing data for research studies? Learn more from our three speakers about the essentials of data management in this webinar!
Released July 2023.
2022 CGA-IGC Research Committee Webinar
"Tips and Tricks for the development of a Clinical Registry"
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Last reviewed: March 2025