The CGA-IGC's clinical and research focus is hereditary gastrointestinal cancer syndromes, including but not limited to:​

  • Familial Adenomatous Polyposis (FAP)

  • MUTYH Associated Polyposis (MAP)

  • Polymerase Proofreading-Associated Polyposis (PPAP)

  • Peutz-Jeghers Syndrome

  • Juvenile Polyposis Syndrome

  • PTEN TumorHamartoma Syndrome

  • Hereditary Mixed Polyposis Syndrome

  • Hereditary Non-Polyposis Colorectal Cancer (HNPCC)

  • Lynch Syndrome

  • Familial Colorectal Cancer Type X

  • Hyperplastic Polyposis/Serrated Polyposis


The Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA) was established in 1995 to improve understanding of the basic science of inherited colorectal cancer and the clinical management of affected families. In 2018, the CGA-ICC moved to change their name to the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC), to be more inclusive of inherited gastrointestinal cancers as a whole.


The vision of the CGA-IGC is to eliminate morbidity and early mortality of hereditary gastrointestinal cancers.


The mission of the CGA-IGC is to advance science and clinical care of inherited gastrointestinal cancers through research and education as the leading authority in the Americas. Through this mission, the CGA-IGC offers the following:

  • Education regarding the clinical management and molecular genetics of inherited gastrointestinal cancer to physicians, allied healthcare professionals, patients, and their families

  • Access to collaborative trials and studies

  • Resources for developing new hereditary registries and supporting their registries

  • A forum for exchange of ideas

  • Multidisciplinary expertise in clinical care, healthcare policy, and research related to hereditary gastrointestinal cancer