The Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC) was established in 1995 to improve understanding of the basic science and the clinical management of inherited gastrointestinal cancers cancer. 


The vision of the CGA-IGC is to eliminate morbidity and early mortality of hereditary gastrointestinal cancers.


The mission of the CGA-IGC is to advance science and clinical care of inherited gastrointestinal cancers through research and education as the leading authority in the Americas. Through this mission, the CGA-IGC offers the following:

  • Education regarding the clinical management and molecular genetics of inherited. gastrointestinal cancer to physicians, allied healthcare professionals, patients, and their families

  • Access to collaborative trials and studies.

  • Resources for developing new hereditary registries and supporting their registries

  • A forum for exchange of ideas.

  • Multidisciplinary expertise in clinical care, healthcare policy, and research related to hereditary gastrointestinal cancer.

The CGA-IGC's clinical, educational and research focus is hereditary gastrointestinal cancer syndromes, including but not limited to:​

  • Lynch Syndrome

  • Familial Adenomatous Polyposis (FAP)

  • MUTYH Associated Polyposis (MAP)

  • Hereditary Diffuse Gastric Cancer Syndrome

  • Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS)

  • Familial Pancreatic Cancer

  • Peutz-Jeghers Syndrome

  • Juvenile Polyposis Syndrome

  • PTEN Hamartoma Syndrome

  • Colon Polyposis of Unknown Etiology (CPUE)

  • Hereditary Mixed Polyposis Syndrome

  • Serrated Polyposis Syndrome

  • Polymerase Proofreading-Associated Polyposis (PPAP)

  • Moderate Penetrance Syndromes (including, but not limited to individuals with pathogenic variants in CHEK2, ATM, APC I1307K, monoallelic MUTYH, etc.)