Joint Webinar with ACG: Chemoprevention in hereditary cancer syndromes – FAP and Lynch Syndrome

If you missed our fifth webinar of the year, or would like to revisit the discussion, the full session is now available on-demand for CGA-IGC members. Not yet a member? You can join here.

In collaboration with the American College of Gastroenterology, this webinar featured Katharine Germansky, MD from Beth Israel Deaconess Medical Center, and Pooja Dharwadkar, MD  from University of California, San Francisco, who delivered an in-depth look at

chemoprevention in hereditary cancer syndromes, focusing on Lynch syndrome and familial adenomatous polyposis (FAP).

Dr. Germansky began by reviewing the characteristics of an ideal chemopreventive agent and the challenges of identifying effective candidates. She highlighted evidence for aspirin, including its mechanism of action and findings from the CAPP2 trial, and discussed decision-making around its use. She also touched on other potential agents such as naproxen, statins, multivitamins, calcium, and the role of chemopreventive interventions in extracolonic cancers using resistant starch or hormonal therapy. She concluded with emerging data on GLP-1 agonists and their potential future role in Lynch syndrome.

Dr. Dharwadkar then shifted focus to FAP, providing an overview of the syndrome, associated cancer risks, and management. She reviewed the goals of chemoprevention in FAP, the mixed evidence for NSAIDs, specifically sulindac and COX-2 inhibitors, and investigational agents such as eflornithine, erlotinib, and mTOR inhibitors. She closed with an overview of current guideline recommendations.

This session offered valuable insights into current and emerging strategies in chemoprevention, and what may lie ahead.

Many thanks to our excellent speakers and moderator for sharing their expertise, and to all who joined the discussion. We look forward to seeing you at the next CGA-IGC webinar!

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Our webinars are a valuable member benefit, and we encourage you to sign up as a member so you can join the live webinars and access our earlier webinar series on demand!

You might also like to explore our podcasts. The CGA-IGC Research Collaboration series or others from the CGA-IGC Podcast Series (Seasons 3, 4, 5, 6 & 7) presented by the CGA-IGC Education Committee. Or, explore our Expert Approach to Hereditary Gastrointestinal Cancers podcast series (Seasons 1 and 2).

We're also on Spotify!

Also, looking for other educational resources? Toolkits? Journal scans?

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